Physical Problems With the Uterus Or Cervix
In some women the uterus is of an unusual shape, while others may suffer from having a cervix, which is weak because of something. To the possible reasons of a weakened cervix may be referred either multiple D&C procedure, or their mothers taking DES during when they were pregnant with them. Still, any of these problems can become a reason of early labour, which usually occurs between 12th – 24th weeks of pregnancy. Miscarriage because of this occurs in about 12% of cases during this period of pregnancy. As the baby keeps growing and developing, especially during the most rapid growth period during this period of pregnancy, the uterus of an irregular shape may simply not get expanded. In case of a weakened cervix, it may begin to open up and the baby will go out. There exist quite effective methods of treatments of any of these problems. Most popular of them is a corrective surgery, conducted on the uterus and a stitch on a cervix, which will not let it open. It is extremely necessary to point out, that in case if these problems do not get treated, it will happen again.
In case if the uterus of an abnormal shape a miscarriage usually occurs because of early labour, however, it can also become a reason of a fetal demise. 

Immune Disorders
Specialists in immune disorders consider that up to 80% of early miscarriages occur because of some problems with the immune system of a woman. However, many “regular” obstetricians and gynecologists keep to be quite resistant to the idea of this type of miscarriage reason as well its treatment methods.

To possible reasons of miscarriages may be referred the following immune problems:
Antiphospholipid antibodies. This problem may become the reason of blood clots development in the placenta. These blood clots either block or slow down significantly the blood supply of the baby, causing either the slowing of a baby’s growth and development or his death. It is possible to make a blood test in order to check if a woman has andiphospholipid antibodies in her organism. These tests are called anticardiolipins, or the associated lupus anticoagulant. The tests themselves are not expensive at all, and sometimes they are possible to be conducted right after the first miscarriage. In case if the results of this test show that the levels of antibodies are high enough to influence the pregnancy, then the treatment consists of taking baby aspirin and sometimes a blood thinner, which is called Heparin. However, it is still possible, though in extremely rare cases, that a woman is found to have Lupus, which may be mild enough, and it will not make any influence on her health, still, some treatment is to be conducted in order to protect her pregnancy. Therefore, a miscarriage because of this problem can occur at any time, the highest risk of it is during the first trimester of pregnancy, as usually the baby will grow normally after the third month of pregnancy. About 10 – 15% of recurring miscarriages are considered to be caused by these antibodies.

Antinuclear antibodies are usually caused by an auto – immune problem in case of Lupus or a Lupus – like syndrome, when the body attacks itself. Prednisone is prescribed as the treatment for this problem. This is a corticosteroid, which is taken with the aim to calm down the process of inflammation of auto – immune disease. It should also be noted, that prednisone is quite a dangerous medicine, and it can potentially become the reason of all kinds of awful side effects, such as bruise marks on the face, swelling and feeling of discomfort. This medicine is usually prescribed, and it is to be taken in cases of an extreme necessity.

Fetal – Blocking Antibodies. This type of problem usually becomes the reason of early miscarriages before 12 weeks of pregnancy, and it is quite often suspected when several miscarriages occur at the same time in the pregnancy. The Fetal - Blocking Antibodies’ work provides the protection from the mother’s immune system, which recognizes the genetic material of a baby’s father as being foreign to her body and attacks it. When the male’s sperm gets into a female’s egg, it does provide foreign material; however, it contains histocompatibility locus antigens (HLA) as well. The HLA of a father “have a talk” with the HLA of a mother, which would normally attack the future the embryo and stimulate the mother’s organism to protect the future baby. However, there are cases, when the genetic material of a father is too similar to the genetic material of a mother, and then the mother’s response is weak enough, and it is not sufficient to prevent her white blood cells from attacking these new cells of an embryo. Unfortunately, there is no standard testing for this problem available so far, and a woman will have to be accepted into one of the few elite clinics, which work in this field. In case if the tests reveal that the woman’s DNA is very similar with the man’s DNA, a woman may receive several injections of her partner’s white blood cells, in hopes that she will get enough of his HLA in her system to stimulate a stronger protective response. This tactic is an expensive and controversial one; however, it succeeds 80% of the time. And, again, it is necessary to point out that the average obstetricians or gynecologists may not be up to date on these immune issues. If a woman has experienced several miscarriages in a row at the same early pregnancy term, she is to look for some specialist, who will be able to determine whether this is a problem, which might influence her babies’ development. However, no one should consider herself being a candidate for the more involved testing, which is expensive enough, and is not usually covered by insurance up until experiencing at least three miscarriages in a row.